Archive for the ‘Glycemic Index’ Category

Inflammation and Diet

Sunday, December 12th, 2010

Inflammation has been linked to hair loss and to diet. A diet that produces systemic inflammation is more likely to exist with hair loss than do anti-inflammatory diets.

Several inflammatory cytokines are induced by oxidant stress.  The fact that cytokines themselves trigger the release of other cytokines and also lead to increased oxidant stress makes them important in chronic inflammation. Toxic cytokines can be influenced by diet modifications.

Over production of pro-inflammatory hormone-like messengers (ex. prostaglandin E2 PGE2) and a lack of production of anti-inflammatory messengers (ex. prostaglandin E1 and E3) is a common cause of inflammation. Omega-3 fatty acids seem to suppress the production of PGE2 and promote the production of the beneficial prostaglandin PGE3. Thus the recommendation is to reduce foods that are high in omega-6 fatty acids and increase the intake of foods high in omega-3. This will lead to more of the beneficial prostaglandins (E1 and E3) and less of the PGE2 linked to inflammation.

Also, Gamma linolinic acid (GLA) induces the production of the anti-inflammatory PGE1.

Arachidonic acid is a precursor to both the pro-inflammatory prostanglandin E2 (PGE2) and the pro-inflammatory cytokine leukotriene B4. Limiting foods that lead to the synthesis of arachidonic acid can also help reduce inflammation.

A high-glycemic index (GI) diet cause excess production of insulin often leading to sharper spikes in insulin. Consuming GI foods could lead to the production of arachidonic acid. So, naturally one should avoid all high GI foods.

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Free-IGF-1 lowers SHBG | Acne, Polycystic Ovarian Syndrome, Hyperinsulinemia and Diet

Sunday, November 21st, 2010

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Arch Dermatol. 2002 Dec;138(12):1584-90.
Acne vulgaris: a disease of Western civilization.

Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J.
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA. cordain@cahs.colostate.edu
Comment in:
* Arch Dermatol. 2002 Dec;138(12):1591-2.
* Arch Dermatol. 2003 Jul;139(7):941; author reply 942-3.
* Arch Dermatol. 2003 Jul;139(7):941-2; author reply 942-3.

Abstract

BACKGROUND: In westernized societies, acne vulgaris is a nearly universal skin disease afflicting 79% to 95% of the adolescent population. In men and women older than 25 years, 40% to 54% have some degree of facial acne, and clinical facial acne persists into middle age in 12% of women and 3% of men. Epidemiological evidence suggests that acne incidence rates are considerably lower in nonwesternized societies. Herein we report the prevalence of acne in 2 nonwesternized populations: the Kitavan Islanders of Papua New Guinea and the Aché hunter-gatherers of Paraguay. Additionally, we analyze how elements in nonwesternized environments may influence the development of acne.

OBSERVATIONS: Of 1200 Kitavan subjects examined (including 300 aged 15-25 years), no case of acne (grade 1 with multiple comedones or grades 2-4) was observed. Of 115 Aché subjects examined (including 15 aged 15-25 years) over 843 days, no case of active acne (grades 1-4) was observed.

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CONCLUSIONS: The astonishing difference in acne incidence rates between nonwesternized and fully modernized societies cannot be solely attributed to genetic differences among populations but likely results from differing environmental factors. Identification of these factors may be useful in the treatment of acne in Western populations.

PMID: 12472346 [PubMed - indexed for MEDLINE]

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Insulin Resistance Disorders and Androgenetic Alopecia

Tuesday, November 9th, 2010

 

There is a link between hair loss (balding) and high insulin levels in blood.  Multiple studies have shown that men who experience early balding (i.e under the age of 35) tend to have high blood insulin levels. There is a strong prevalence of insulin resistance with androgenetic alopecia (AGA), and more troublesome, there’s an association of androgenetic alopecia (AGA) with insulin-resistance-related disorders such as ischemic heart disease and serious cardiovascular events.

The above is not only true in men. An association between AGA and anthropometric abnormalities (linked with insulin resistance and heredity) was found in women aged 63 years. Female AGA has usually been linked with hyper-androgenism and hirsutism and, most recently, also with polycystic ovarian syndrome (PCOS). Polycystic ovarian syndrome is quite common among Caucasian women, and its association with insulin resistance is well documented.

Further, epidemiological studies have associated androgenetic alopecia (AGA) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance

The following studies show that AGA and high blood insulin levels are connected. The first dated Sept 2000, then June 2003, June 2006, and Oct 2009.

Lancet. 2000 Sep 30;356(9236):1165-6 “Early androgenetic alopecia as a marker of insulin resistance” Found that men under the age of 35 with an early onset of alopecia aged showed a “strikingly increased risk of hyperinsulinaemia and insulin-resistance-associated disorders” (i.e obesity, hypertension, and dyslipidemia). That early androgenetic alopecia could be a clinical marker of insulin resistance.

J Cardiovasc Risk. 2003 Jun;10(3):227-31. “Hair loss, insulin resistance, and heredity in middle-aged women…” Found that female with some markers of insulin resistance have significantly increased risk for female AGA. Paternal history of alopecia seemed to be more common in female AGA compared to women with normal or minimal loss of hair.

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