The Patterned Baldness Multifactorial Model: Hormonal-Immune Interactions

During research into male pattern baldness, so called androgenic alopecia, I found an abstract of a study published in April of 1999 that talked about AGA and the “sensitivity to the male sex hormones” relating to the androgen metabolism model. This abstract went further and mentioned a lesser-known model referred to as the “multifactorial model”.

In this model, “hormones affect the hair follicle in a way that causes it to be perceived as a foreign body by the immune system, which then mounts an attack.” [15] This study suggests hormonal/immune interactions. The immune system is usually looked at in cases of Alopecia Areata but not AGA. The topic of Alopecia Areata is beyond the scope of this paper.

The author believes further research is needed to better determine the extent of hormonal/immune interactions on MPB.

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The above was written on July 22, 2010






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