Posts Tagged ‘Environmental’

Polygenetic and Poly-etc..

Wednesday, December 14th, 2011

The predisposition is not only genetic (polygenic) but also environmental. Every single experience you had in life, every food, every substance that entered your system, and ones that are lacking.. all come into a complex play with your genes and body systems, even your mind-set, and produce physical outcomes.

Is Patterned Hair Loss Genetic?

Monday, January 3rd, 2011

Yes and no. Genetics do play a role by causing a predisposition or a susceptibility to hair loss in individuals. However, saying something is genetic does not mean it is caused by one gene alone.  It is becoming evident the susceptibility to hair loss is driven by multiple genes, not just one. Thus what we consider male pattern baldness is Polygenic.

As more discoveries in the human genome were made researchers began to see previously unknown genetic complexities that played a role in the inheritance or manifestation of AGA.

As of March 2008 only one gene was identified to be related with AGA: “The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date.” [8] Quickly after, by September 2008, a better understanding of the polygenic nature of AGA was acquired: “Androgenetic alopecia (AGA) is a common heritable polygenic disorder whose genetics is not fully understood, even though it seems to be X-linked.” [16]
Based on current knowledge, we can define AGA by saying that inheritance of AGA traits is polygenic, meaning the inheritance has many, or several, different sources of origin.

Written on July, 22 2010

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Polygenic is a better word to associate with male pattern baldness than Androgenic since research found non-androgen dependent pathways involved with male pattern baldness. I am also of the opinion that genetics only play a role but do not determine the outcome. Research does show that environmental factors can trump genetics, they can trigger genetics, alter genes or prevent the expression of certain treats. Exercise, a good diet, a clean environment, a good mindset, and healthy gut flora all contribute to optimal health and can trump genetic predisposition.


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