Posts Tagged ‘Finasteride’

Study: Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group

Sunday, September 18th, 2011

 -:: This Abstract is posted here for posterity and archival purposes only ::-

J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):578-89.
Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.
Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ.
Source

Department of Clinical Research, Merck Research Laboratories, Rahway, NJ 07065, USA.

Abstract
BACKGROUND:

Androgenetic alopecia (male pattern hair loss) is caused by androgen-dependent miniaturization of scalp hair follicles, with scalp dihydrotestosterone (DHT) implicated as a contributing cause. Finasteride, an inhibitor of type II 5alpha-reductase, decreases serum and scalp DHT by inhibiting conversion of testosterone to DHT.

OBJECTIVE:

Our purpose was to determine whether finasteride treatment leads to clinical improvement in men with male pattern hair loss.

METHODS:

In two 1-year trials, 1553 men (18 to 41 years of age) with male pattern hair loss received oral finasteride 1 mg/d or placebo, and 1215 men continued in blinded extension studies for a second year. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, and review of photographs by an expert panel.

RESULTS:

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Study: Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study

Sunday, September 18th, 2011

Comment by Ethan:

This study is important because it reminds us that T conversion to DHT occurs in low oxygen environments, that the muscles (or anything) that constricts blood flow also reduces the availability of Oxygen in the scalp and dermal papilla.  Thus, relaxing these muscles, via botox (something I would not recommend since botox is a toxin), other approaches to relax the muscles and/or increase circulation and Oxygen levels include: various types of scalp massages, acupuncture, diet and nutrition, reducing inflammation, relaxation exercises etc is helpful to men with hair loss resulting from a genetic sensitivity to DHT.

 

 -:: This Abstract is posted here for posterity and archival purposes only ::-

Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study

Freund, Brian J. D.D.S., M.D.; Schwartz, Marvin D.D.S., M.Sc.

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Plastic and Reconstructive Surgery . 126(5):246e-248e, November 2010.

doi: 10.1097/PRS.0b013e3181ef816d

Author Information

Crown Institute; Pickering, Ontario, Canada

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The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia

Friday, November 19th, 2010

-::- Note: The below is being posted here for archival purposes only (for preservation)-::-

J Am Acad Dermatol. 2003 Aug;49(2):229-33.

The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia.
Tang L, Bernardo O, Bolduc C, Lui H, Madani S, Shapiro J.

Division of Dermatology, The University of British Columbia, Vancouver Hospital, Canada.

BACKGROUND: It is generally believed that dihydrotestosterone is one of the pivotal mediators of hair loss in androgenetic alopecia (AGA). Finasteride, which blocks the conversion of testosterone to dihydrotestosterone, has now become an integral part of the current treatment approaches for male AGA. Several lines of evidence support the notion that dermal papilla (DP) cells represent the androgen target within the hair follicle. The specific molecular regulators modulated by androgens within hair follicles in the balding scalp are unknown.

OBJECTIVE: The purpose of this study was to identify and quantify changes in expression of specific molecular hair growth regulators in DP of men with AGA treated with finasteride and correlate these findings to clinical efficacy.

METHODS: Biopsy specimens were collected from 9 male patients from both the balding area and nonbalding occipital area before and after 4 months of finasteride therapy. DP were microdissected and total RNA was extracted from an equal number of DP from each biopsy specimen. The expression of various cytokines, including insulin-like growth factor (IGF)-1, was determined by reverse transcription polymerase chain reaction. The signals were detected by autoradiography. All 9 patients were given finasteride for 1 year and evaluated for efficacy at month 12. Efficacy was graded on a 7-point scale on the basis of comparison with initial baseline photography.

RESULTS: IGF-1 was up-regulated by finasteride treatment in 4 of 9 patients. Among the patients with increased IGF-1 expression, 3 of them showed moderate clinical improvement after 12 months of treatment and another patient remained unchanged. In contrast, 3 patients with decreased IGF-1 expression in the balding scalp showed clinical worsening after 12 months. The other 2 patients without noticeable change in IGF-1 expression showed either slight improvement or no change in their hair condition.

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