Posts Tagged ‘Gene Expression’

Polygenetic and Poly-etc..

Wednesday, December 14th, 2011

The predisposition is not only genetic (polygenic) but also environmental. Every single experience you had in life, every food, every substance that entered your system, and ones that are lacking.. all come into a complex play with your genes and body systems, even your mind-set, and produce physical outcomes.

Study: Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study

Sunday, September 18th, 2011

Comment by Ethan:

This study is important because it reminds us that T conversion to DHT occurs in low oxygen environments, that the muscles (or anything) that constricts blood flow also reduces the availability of Oxygen in the scalp and dermal papilla.  Thus, relaxing these muscles, via botox (something I would not recommend since botox is a toxin), other approaches to relax the muscles and/or increase circulation and Oxygen levels include: various types of scalp massages, acupuncture, diet and nutrition, reducing inflammation, relaxation exercises etc is helpful to men with hair loss resulting from a genetic sensitivity to DHT.

 

 -:: This Abstract is posted here for posterity and archival purposes only ::-

Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study

Freund, Brian J. D.D.S., M.D.; Schwartz, Marvin D.D.S., M.Sc.

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Plastic and Reconstructive Surgery . 126(5):246e-248e, November 2010.

doi: 10.1097/PRS.0b013e3181ef816d

Author Information

Crown Institute; Pickering, Ontario, Canada

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Is Patterned Hair Loss Genetic?

Monday, January 3rd, 2011

Yes and no. Genetics do play a role by causing a predisposition or a susceptibility to hair loss in individuals. However, saying something is genetic does not mean it is caused by one gene alone.  It is becoming evident the susceptibility to hair loss is driven by multiple genes, not just one. Thus what we consider male pattern baldness is Polygenic.

As more discoveries in the human genome were made researchers began to see previously unknown genetic complexities that played a role in the inheritance or manifestation of AGA.

As of March 2008 only one gene was identified to be related with AGA: “The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date.” [8] Quickly after, by September 2008, a better understanding of the polygenic nature of AGA was acquired: “Androgenetic alopecia (AGA) is a common heritable polygenic disorder whose genetics is not fully understood, even though it seems to be X-linked.” [16]
Based on current knowledge, we can define AGA by saying that inheritance of AGA traits is polygenic, meaning the inheritance has many, or several, different sources of origin.

Written on July, 22 2010

Comment:

Polygenic is a better word to associate with male pattern baldness than Androgenic since research found non-androgen dependent pathways involved with male pattern baldness. I am also of the opinion that genetics only play a role but do not determine the outcome. Research does show that environmental factors can trump genetics, they can trigger genetics, alter genes or prevent the expression of certain treats. Exercise, a good diet, a clean environment, a good mindset, and healthy gut flora all contribute to optimal health and can trump genetic predisposition.

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