Posts Tagged ‘IGFBP-3’

Glycemic Index, Insulin resistance and IGF-1

Monday, December 13th, 2010

There is a link between hair loss and Insulin resistance, glucose intolerance and IGF-1.

The studies below show that men with vertex balding had increased (higher) levels of circulating Insulin Growth Factor-1 (IGF-1) and decreased (lower) levels of circulating Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3).

J Am Acad Dermatol. 1999 Feb;40(2 Pt 1):200-3. “Hormones and hair patterning in men: a role for insulin-like growth factor 1?”

evaluated the function of “sex steroids”, “sex hormone-binding globulin” (SHBG), and “insulin-like growth factor” (IGF-1) in determining hair-loss patterning in men. This study found that “for each 59 ng/mL increase in IGF-1, the odds of having vertex baldness doubled” and that “Testosterone, SHBG, and IGF-1 may be important in determining hair patterning in men.”

J Am Acad Dermatol. 2000 Jun;42(6):1003-7. “Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3″ Found that  “Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.”

A link between IGF-1 and glucose intolerance / insulin resistance

Studies suggest that insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 (IGFBP-1) could be important determinants of glucose homoeostasis. The study below indicates that low IGF-1 levels are associated with the development of insulin resistance and provides “further evidence for the possible protective role of IGF-I against development of glucose intolerance.”

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Calorie-restriction, Protein-restriction and free-IGF-1 / SHBG

Monday, November 22nd, 2010

Studies pertaining to Calorie-restriction (CR), Protein-restriction (PR) and free-IGF-1 and SHBG.

1)

Br J Cancer. 2000 Jul;83(1):95-7.
Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men.

Allen NE, Appleby PN, Davey GK, Key TJ.
Cancer Epidemiology Unit, Imperial Cancer Research Fund, Radcliffe Infirmary, Oxford, UK.

Abstract

Mean serum insulin-like growth factor-I was 9% lower in 233 vegan men than in 226 meat-eaters and 237 vegetarians (P = 0.002).

Vegans had higher testosterone levels than vegetarians and meat-eaters, but this was offset by higher sex hormone binding globulin, and there were no differences between diet groups in free testosterone, androstanediol glucuronide or luteinizing hormone.

PMID: 10883675 [PubMed - indexed for MEDLINE]PMCID: PMC2374537

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http://www.ncbi.nlm.nih.gov/pubmed/10883675

Full text PDF: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374537/pdf/83-6691152a.pdf
PDF file: Hormones and diet-83-6691152a.pdf

2)

Aging Cell. 2008 Oct;7(5):681-7.
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO.

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Free-IGF-1 lowers SHBG | Acne, Polycystic Ovarian Syndrome, Hyperinsulinemia and Diet

Sunday, November 21st, 2010

1)

Arch Dermatol. 2002 Dec;138(12):1584-90.
Acne vulgaris: a disease of Western civilization.

Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J.
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA. cordain@cahs.colostate.edu
Comment in:
* Arch Dermatol. 2002 Dec;138(12):1591-2.
* Arch Dermatol. 2003 Jul;139(7):941; author reply 942-3.
* Arch Dermatol. 2003 Jul;139(7):941-2; author reply 942-3.

Abstract

BACKGROUND: In westernized societies, acne vulgaris is a nearly universal skin disease afflicting 79% to 95% of the adolescent population. In men and women older than 25 years, 40% to 54% have some degree of facial acne, and clinical facial acne persists into middle age in 12% of women and 3% of men. Epidemiological evidence suggests that acne incidence rates are considerably lower in nonwesternized societies. Herein we report the prevalence of acne in 2 nonwesternized populations: the Kitavan Islanders of Papua New Guinea and the Aché hunter-gatherers of Paraguay. Additionally, we analyze how elements in nonwesternized environments may influence the development of acne.

OBSERVATIONS: Of 1200 Kitavan subjects examined (including 300 aged 15-25 years), no case of acne (grade 1 with multiple comedones or grades 2-4) was observed. Of 115 Aché subjects examined (including 15 aged 15-25 years) over 843 days, no case of active acne (grades 1-4) was observed.

CONCLUSIONS: The astonishing difference in acne incidence rates between nonwesternized and fully modernized societies cannot be solely attributed to genetic differences among populations but likely results from differing environmental factors. Identification of these factors may be useful in the treatment of acne in Western populations.

PMID: 12472346 [PubMed - indexed for MEDLINE]

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Men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1

Sunday, November 21st, 2010

J Am Acad Dermatol. 2000 Jun;42(6):1003-7.
Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.

Platz EA, Pollak MN, Willett WC, Giovannucci E.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Abstract

BACKGROUND: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined.

OBJECTIVE: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men.

METHODS: Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw.

RESULTS: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1. 31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3 (957 ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88).

CONCLUSION: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.

PMID: 10827403 [PubMed - indexed for MEDLINE]

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Protein is a Stimulator of Free IGF-1

Friday, November 19th, 2010

It seems that protein (in meat or dairy) is a stimulator of free-IGF-1

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Aging Cell. 2008 Oct;7(5):681-7.
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO.

Division of Geriatrics & Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA. lfontana@dom.wustl.edu

Abstract

Reduced function mutations in the insulin/IGF-I signaling pathway increase maximal lifespan and health span in many species. Calorie restriction (CR) decreases serum IGF-1 concentration by ~40%, protects against cancer and slows aging in rodents. However, the long-term effects of CR with adequate nutrition on circulating IGF-1 levels in humans are unknown.

Here we report data from two long-term CR studies (1 and 6 years) showing that severe CR without malnutrition did not change IGF-1 and IGF-1 : IGFBP-3 ratio levels in humans. In contrast, total and free IGF-1 concentrations were significantly lower in moderately protein-restricted individuals. Reducing protein intake from an average of 1.67 g kg(-1) of body weight per day to 0.95 g kg(-1) of body weight per day for 3 weeks in six volunteers practicing CR resulted in a reduction in serum IGF-1 from 194 ng mL(-1) to 152 ng mL(-1).

These findings demonstrate that, unlike in rodents, long-term severe CR does not reduce serum IGF-1 concentration and IGF-1 : IGFBP-3 ratio in humans. In addition, our data provide evidence that protein intake is a key determinant of circulating IGF-1 levels in humans, and suggest that reduced protein intake may become an important component of anticancer and anti-aging dietary interventions.

Source: http://www.ncbi.nlm.nih.gov/pubmed/18843793
Full: http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2008.00417.x/full

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J Am Acad Dermatol. 2000 Jun;42(6):1003-7. “Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3″

Wednesday, August 18th, 2010

-::- Note: The below is published here for archival purposes -::-

J Am Acad Dermatol. 2000 Jun;42(6):1003-7.

Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.

Platz EA, Pollak MN, Willett WC, Giovannucci E.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

Abstract

BACKGROUND: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined.

OBJECTIVE: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men.

METHODS: Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw.

RESULTS: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1. 31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3 (957 ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88).

CONCLUSION: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.

PMID: 10827403 [PubMed - indexed for MEDLINE]

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