Posts Tagged ‘Lithium’

About Lithium

Tuesday, May 31st, 2011


About 10-20mg of lithium per day may help support signal-carrying pathways in the brain, and protect and revitalize brain cells which can promote improvement in mood.


Lithium is an alkali metal in the same family as sodium and potassium. In low doses (much less than those used to treat depression), lithium has anti-aging effects. It protects brain cells from damage from excitotoxins like glutamate, inhibits beta-amlyloid secretion (a hallmark of Alzheimer’s disease), and increases human brain grey matter, among other things. Lithium makes uric acid more soluble so it doesn’t crystallize into painful “needles” and cause gout. And it inhibits reproduction of viruses—herpes simplex, adenovirus (cold), and measles viruses.

Dr. Donald Miller


You could get it via Lithium Aspartate or Lithium Orotate:
Lithate (lithium aspartate) – 20 mg/day of elemental lithium
Lithium Orotate, pill or powder (topical use)




DMSO + Lithium Pharmaceutical Patent

Sunday, September 26th, 2010

-::- Note: The below is being posted here for archival purposes only (for preservation)-::-

Title: Methods of modulating hair growth

United States Patent: 6,924,141

Issued: August 2, 2005

Inventors: Morgan; Bruce A. (Lexington, MA); Kishimoto; Jiro (Yokahama, JP); Burgeson; Robert (Marblehead, MA)

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
An automatic insert of some related ads:

Thanks for your patronage. Article continues below:
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Assignee: The General Hospital Corporation (Boston, MA)

Appl. No.: 822722

Filed: March 30, 2001


Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

Wednesday, July 28th, 2010

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

1. Philippe Clément-Lacroix*,†, 2. Minrong Ai†,‡, 3. Frederic Morvan†,§, 4. Sergio Roman-Roman*, 5. Béatrice Vayssière*, 6. Cecille Belleville*, 7. Kenneth Estrera§, 8. Matthew L. Warman‡, 9. Roland Baron*,§, and 10. Georges Rawadi*,¶


One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3ß and the consequent activation of canonical Wnt signaling. Because deficient Wnt signaling has been implicated in disorders of reduced bone mass, we tested whether lithium could improve bone mass in mice. We gavage-fed lithium chloride to 8-week-old mice from three different strains (Lrp5 -/-, SAMP6, and C57BL/6) and assessed the effect on bone metabolism after 4 weeks of therapy. Lrp5 -/- mice lack the Wnt coreceptor low-density lipoprotein receptor-related protein 5 and have markedly reduced bone mass. Lithium, which is predicted to act downstream of this receptor, restored bone metabolism and bone mass to near wild-type levels in these mice. SAMP6 mice have accelerated osteoporosis due to inadequate osteoblast renewal. Lithium significantly improved bone mass in these mice and in wild-type C57BL/6 mice. We found that lithium activated canonical Wnt signaling in cultured calvarial osteoblasts from Lrp5 -/- mice ex vivo and that lithium-treated mice had increased expression of Wnt-responsive genes in their bone marrow cells in vivo. These data lead us to conclude that lithium enhances bone formation and improves bone mass in mice and that it may do so via activation of the canonical Wnt pathway. Lithium has been used safely and effectively for over half a century in the treatment of bipolar illness. Prospective studies in patients receiving lithium should determine whether it also improves bone mass in humans.


? ¶ To whom correspondence should be addressed. E-mail:

? † P.C.-L., M.A., and F.M. contributed equally to this work.


Disclaimer: I must say this: The information presented herein is for informational purposes only. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements, making dietary changes, or before making any changes in prescribed medications.
All posts are strictly opinions meant to foster debate, education, comment, teaching, scholarship and research under the "fair use doctrine" in Section 107 of U.S. Code Title 17. No statement of fact is made and/or should be implied. Please verify all the articles on this site for yourself. The Information found here should in no way to be construed as medical advice. If You have a health issue please consult your professional medical provider. Everything here is the authors own personal opinion as reported by authors based on their personal perception and interpretation as a part of authors freedom of speech. Nothing reported here should be taken as medical advice, diagnosis or prescription; medical advice should only be taken from your health care provider. Consume the information found on this web site under your own responsibility. Please, do your own research; reach your own conclusions, and take personal responsibility and personal control of your health.