Posts Tagged ‘Mice Studies’

Study: Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats

Friday, July 1st, 2011

-:: This Abstract is posted here for posterity and archival purposes only ::-

Am J Clin Nutr. 1993 Feb;57(2 Suppl):240S-243S.

Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats.

Beckett GJ, Nicol F, Rae PW, Beech S, Guo Y, Arthur JR.

University Department of Clinical Chemistry, Royal Infirmary, Edinburgh, UK.

Abstract

This paper compares the effects of combined iodine and selenium deficiency, of single deficiencies of these trace elements, and of no deficiency on thyroid hormone metabolism in rats.

In rats deficient in both trace elements, thyroidal triiodothyronine (T3), thyroidal thyroxin (T4), thyroidal total iodine, hepatic T4, and plasma T4 were significantly lower, and plasma thyroid-stimulating hormone (TSH) and thyroid weight were significantly higher than in rats deficient in iodine alone.

Plasma and hepatic T3 concentrations were similar in the dietary groups. Hepatic type I iodothyronine deiodinase (ID-I) activity was inhibited by selenium deficiency irrespective of the iodine status. Type II deiodinase (ID-II) activity in the brain was significantly higher and in pituitary, significantly lower in combined deficiency than in iodine deficiency alone.

These data show that selenium can play an important role in determining the severity of the hypothyroidism associated with iodine deficiency.

PMID:
8427196
[PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/pubmed/8427196

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On Mice Studies

Thursday, June 16th, 2011

A quick note on studies involving mice:

Many studies on hair-loss and life-span have been conducted on mice. These studies offer some possibly intriguing leads to follow, however we must remember that mice are not humans.

Further, in my opinion, one must note that many studies do not differentiate between good fats/bad fats, good carbs/bad carbs, and other possible environmental factors. Further, studies involving 12, 40, or even 100 mice might not be large enough to offer a solid lead to follow in humans or to experiment with clinically.

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Study: Fat maintenance is a predictor of the murine lifespan response to dietary restriction

Thursday, June 16th, 2011

This article archives the study titled: Fat maintenance is a predictor of the murine lifespan response to dietary restriction:

1) Article

Article: Mouse study turns fat-loss/longevity link on its head – Science Daily, 5/3/11

“studied the effect of food restriction on fat and weight loss in 41 genetically different strains of mice. The scientists then correlated the amount of fat reduction to life span … The answer: Mice that maintained their fat actually lived longer. Those that lost fat died earlier … People are best advised to adopt a moderate approach, not losing all fat but definitely not keeping unhealthy amounts of fat, either … None of the mice in this study were what we would consider to be obese”

Archived article: Mouse-Study-Turns-Fat-Loss-longevity-Link-on-Its-Head.pdf

2) Journal reference:

Chen-Yu Liao, Brad A. Rikke, Thomas E. Johnson, Jonathan A.L. Gelfond, Vivian Diaz, James F. Nelson. Fat Maintenance Is a Predictor of the Murine Lifespan Response to Dietary Restriction. Aging Cell, 2011; DOI: 10.1111/j.1474-9726.2011.00702.x

Journal Summary:

Fat maintenance is a predictor of the murine lifespan response to dietary restriction     1. Chen-Yu Liao1,2,    2. Brad A. Rikke3,    3. Thomas E. Johnson3,4,    4. Jonathan A. L. Gelfond2,5,    5. Vivian Diaz2,    6. James F. Nelson1,2  Article first published online: 25 APR 2011  DOI: 10.1111/j.1474-9726.2011.00702.x
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