Posts Tagged ‘Reactive Oxygen Species’

Nature. 2006 Apr 13 “Reactive oxygen species have a causal role in multiple forms of insulin resistance”

Thursday, May 26th, 2011

Nature. 2006 Apr 13;440(7086):944-8.
Reactive oxygen species have a causal role in multiple forms of insulin resistance.
Houstis N, Rosen ED, Lander ES.
Source

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA.
Abstract

Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings. Little is known about why insulin resistance occurs in so many contexts. Do the various insults that trigger insulin resistance act through a common mechanism? Or, as has been suggested, do they use distinct cellular pathways? Here we report a genomic analysis of two cellular models of insulin resistance, one induced by treatment with the cytokine tumour-necrosis factor-alpha and the other with the glucocorticoid dexamethasone. Gene expression analysis suggests that reactive oxygen species (ROS) levels are increased in both models, and we confirmed this through measures of cellular redox state. ROS have previously been proposed to be involved in insulin resistance, although evidence for a causal role has been scant. We tested this hypothesis in cell culture using six treatments designed to alter ROS levels, including two small molecules and four transgenes; all ameliorated insulin resistance to varying degrees. One of these treatments was tested in obese, insulin-resistant mice and was shown to improve insulin sensitivity and glucose homeostasis. Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings.

PMID:
16612386
[PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/sites/entrez/16612386?dopt=Abstract&holding=f1000,f1000m,isrctn

Calorie Restriction Research

Tuesday, May 24th, 2011

Additional research on Calorie Restriction.

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Curcumin Supplements

Thursday, January 6th, 2011

My favorite curcumin supplement is

The Jarrow Curcumin 95% “Cucrcumine 95 250mg”

Description

* Turmeric 18:1 Concentrate
* Antioxidant Protection
* Dietary Supplement

Curcumin 95 is an 18:1 concentrate of the antioxidants found in the spice turmeric root. Curcumin 95 contains 95% curcuminoids (including curcumin, demethoxycurcumin and bisdemethoxycurcumin), which are antioxidants. Specifically, curcumin and it derivatives protect DNA against oxidative damage induced by reactive oxygen species.

Please note, some people who took the curcumin/bioperine combination reported an increased inflammation in the scalp.  Every time you take a new supplement listen to your body, sense the scalp and how your body feels that day.

Reviews from iHerb:

11 of 11  people found the following review helpful
Elizabeth B January 13, 2007
From Florida
curcumin has anti cancer properties. I have been taking 2 gms (4 capsules) per day since shortly after diagnosis with stage 4 breast cancer a year ago. Went into remission within 3 months, all tumors have disappeared, am now in remission with no evidence of disease for 8 months.
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4 of 4 people found the following review helpful
No more sweat smell! November 07, 2008
From Tennessee
In addition to being a wonderful anti-oxidant, after using this for a couple of weeks in the summer, I found that my sweat did not smell. One thing though, if your blood sugar tends to run low, it takes about a month for your body to get used to it. Keep honey around, because your blood sugar can drop very quickly.
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2 of 2 people found the following review helpful
Customer January 13, 2009
From Colorado
Curcumin is recommended for several conditions. I use because I read it helps prevent Alzheimer’s.
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2 of 2 people found the following review helpful
Great for bone spurs February 02, 2009
From North Carolina
Discovered online that curcumin is a great anti-inflammatory. Occasionally I have sharp pain in my back that is caused by bone spurs. I’ll take a capsule every few hours and by the next day the pain is almost all gone. once the pain is gone I only take 1 a day. To me this is incredible because I could have pain that lasted for 2 weeks. Love curcumin.
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140+ Reasons Why Sugar Is Ruining Your Health

Sunday, November 28th, 2010

The following list was written by Nancy Appleton, Ph.D. (visit her very informative website www.nancyappleton.com), the author of the book Lick The Sugar Habit.

In addition to throwing off the body’s homeostasis, excess sugar may result in a number of other significant consequences. The following is a listing of some of sugar’s metabolic consequences from a variety of medical journals and other scientific publications.

141 Reasons Sugar Ruins Your Health

(Just Kidding, it’s 143)

By Nancy Appleton PhD & G.N. Jacobs

Excerpted from Suicide by Sugar

Used with permission

1. Sugar can suppress your immune system.

2. Sugar upsets the mineral relationships in the body.

3. Sugar can cause juvenile delinquency in children.

4. Sugar eaten during pregnancy and lactation can influence muscle force production in offspring, which can affect an individual’s ability to exercise.

5. Sugar in soda, when consumed by children, results in the children drinking less milk.

6. Sugar can elevate glucose and insulin responses and return them to fasting levels slower in oral contraceptive users.

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J Mol Med. 2008 Jun;86(6):729-34. “Aldosterone in salt-sensitive hypertension and metabolic syndrome”

Sunday, August 1st, 2010

J Mol Med. 2008 Jun;86(6):729-34. Epub 2008 Apr 25.

Aldosterone in salt-sensitive hypertension and metabolic syndrome.

Fujita T.

Department of Nephrology and Endocrinology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. fujita-dis@h.u-tokyo.ac.jp

Abstract

Metabolic syndrome, which is caused by obesity, is now a global pandemic. Metabolic syndrome is an aggregation of hypertension, diabetes and dyslipidaemia. Insulin resistance is a key factor in the development of these components of metabolic syndrome.

Concerning the mechanism for the development of hypertension in metabolic syndrome, the lack of insulin resistance in the kidney increases sodium reabsorption by hyperinsulinaemia, leading to sodium retention in the body, and resultant salt-sensitive hypertension.

Moreover, hyperaldosteronism, which is caused by adipocyte-derived aldosterone-releasing factors, induces not only salt-sensitive hypertension, but also proteinuria in obese hypertensive rats.

Salt loading markedly aggravates proteinuria and induces cardiac diastolic dysfunction in obese hypertensive rats, suggesting that salt and aldosterone exert unfavourable synergistic actions on the cardiovascular system, possibly through the overproduction of oxidative stress.

In turn, reactive oxygen species (ROS), which are induced by adipokines such as tumour necrosis factor-alpha, non-esterified fatty acids, angiotensinogen etc., can activate the mineralocorticoid (MR) receptor, in an aldosterone-independent fashion.

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