Posts Tagged ‘Wnt Signaling’

DMSO + Lithium Pharmaceutical Patent

Sunday, September 26th, 2010

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Title: Methods of modulating hair growth

United States Patent: 6,924,141

Issued: August 2, 2005

Inventors: Morgan; Bruce A. (Lexington, MA); Kishimoto; Jiro (Yokahama, JP); Burgeson; Robert (Marblehead, MA)

Assignee: The General Hospital Corporation (Boston, MA)

Appl. No.: 822722

Filed: March 30, 2001

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

Wednesday, July 28th, 2010

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

1. Philippe Clément-Lacroix*,†, 2. Minrong Ai†,‡, 3. Frederic Morvan†,§, 4. Sergio Roman-Roman*, 5. Béatrice Vayssière*, 6. Cecille Belleville*, 7. Kenneth Estrera§, 8. Matthew L. Warman‡, 9. Roland Baron*,§, and 10. Georges Rawadi*,¶

Abstract

One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3ß and the consequent activation of canonical Wnt signaling. Because deficient Wnt signaling has been implicated in disorders of reduced bone mass, we tested whether lithium could improve bone mass in mice. We gavage-fed lithium chloride to 8-week-old mice from three different strains (Lrp5 -/-, SAMP6, and C57BL/6) and assessed the effect on bone metabolism after 4 weeks of therapy. Lrp5 -/- mice lack the Wnt coreceptor low-density lipoprotein receptor-related protein 5 and have markedly reduced bone mass. Lithium, which is predicted to act downstream of this receptor, restored bone metabolism and bone mass to near wild-type levels in these mice. SAMP6 mice have accelerated osteoporosis due to inadequate osteoblast renewal. Lithium significantly improved bone mass in these mice and in wild-type C57BL/6 mice. We found that lithium activated canonical Wnt signaling in cultured calvarial osteoblasts from Lrp5 -/- mice ex vivo and that lithium-treated mice had increased expression of Wnt-responsive genes in their bone marrow cells in vivo. These data lead us to conclude that lithium enhances bone formation and improves bone mass in mice and that it may do so via activation of the canonical Wnt pathway. Lithium has been used safely and effectively for over half a century in the treatment of bipolar illness. Prospective studies in patients receiving lithium should determine whether it also improves bone mass in humans.
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? ¶ To whom correspondence should be addressed. E-mail: georges.rawadi@prostrakan.com.
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? † P.C.-L., M.A., and F.M. contributed equally to this work.
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